RING1 anticorps (AA 35-39)

N° du produit ABIN5689347

Cet anticorps Lapin Polyclonal détecte spécifiquement RING1 dans WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour RING1 anticorps (AA 35-39) (ABIN5689347)

Antigène: RING1 (Ring Finger Protein 1 (RING1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RING1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RING1 anticorps

Épitope: AA 35-39

Specificité: This antibody detects endogenous level of total Ring1A protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: Ring1A antibody was raised against a peptide sequence around aa.35~39 ( I-A-V-S-P) derived from Human Ring1A.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur RING1

Antigène: RING1 (Ring Finger Protein 1 (RING1))

Autre désignation: Ring1A

Sujet: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Poids moléculaire: 58 kDa

ID gène: 6015

NCBI Accession: NP_002922

UniProt: Q06587