LIN28A anticorps (AA 1-5)

N° du produit ABIN5689572

Cet anticorps Lapin Polyclonal détecte spécifiquement LIN28A dans WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour LIN28A anticorps (AA 1-5) (ABIN5689572)

Antigène: LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LIN28A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-LIN28A anticorps

Épitope: AA 1-5

Specificité: This antibody detects endogenous levels of total Lin28 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: Lin28 antibody was raised against a peptide sequence around aa. 1~5 (M-G-S-V-S) derived from Human Lin28 .

Information d'application

Indications d'application: Western Blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur LIN28A

Antigène: LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

Autre désignation: Lin28

Sujet: Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.

Poids moléculaire: 26 kDa

ID gène: 79727

NCBI Accession: NP_078950

UniProt: Q9H9Z2

Pathways: Stem Cell Maintenance