PK (pThr446) anticorps

N° du produit ABIN5689715

Cet anticorps anti-PK Polyclonal Lapin (ABIN5689715) détecte spécifiquement PK dans IF, IHC et WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PK (pThr446) anticorps (ABIN5689715)

Antigène: PK

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)

Détail du produit

Épitope: pThr446

Specificité: This antibody detects endogenous level of PKR only when phosphorylated at threonine 446.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Immunogène: PKR (Phospho-Thr446) antibody was raised against a peptide sequence around phosphorylation site of threonine 446 (K-R-T (p) -R-S) derived from Human PKR.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détail du antigène

Antigène: PK

Sujet: Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

Poids moléculaire: 68 kDa

ID gène: 5610

NCBI Accession: NP_001129123

UniProt: P19525