Beclin 2 anticorps (AA 30-80)

N° du produit ABIN5689901

Cet anticorps anti-Beclin 2 Polyclonal Lapin (ABIN5689901) détecte spécifiquement Beclin 2 dans WB, IHC (p), ELISA et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Beclin 2 anticorps (AA 30-80) (ABIN5689901)

Antigène: Beclin 2 (BECN1L1) (Beclin-1-Like Protein 1 (BECN1L1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Beclin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunofluorescence (IF)

Détail du produit anti-Beclin 2 anticorps

Épitope: AA 30-80

Specificité: Beclin 2 antibody is human specific. At least two isoforms of Beclin 2 are known to exist, this antibody will only detect the longer isoform. Beclin 2 antibody is predicted to not cross-react with Beclin 1.

Purification: Beclin 2 antibody is affinity chromatography purified via peptide column.

Immunogène: Beclin 2 antibody was raised against a 16 amino acid peptide near the amino terminus of human Beclin 2.

The immunogen is located within amino acids 30 - 80 of Beclin 2.

Isotype: IgG

Information d'application

Indications d'application: Beclin 2 antibody can be used for detection of Beclin 2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Beclin 2 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Beclin 2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur Beclin 2

Antigène: Beclin 2 (BECN1L1) (Beclin-1-Like Protein 1 (BECN1L1))

Autre désignation: Beclin 2

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin 2 is a mammalian specific homolog of the autophagy protein Beclin 1 (3). Like Beclin 1, Beclin 2 interacts with Bcl-2 and class III PI3K complex components. However, Beclin 2 functions in an additional lysosomal degradation pathway and is required for ligand-induced endolysosomal degradation of several G protein-coupled receptors (3). Beclin 2 is also required for agonist-induced lysosome-mediated degradation of EGFR in lung cancer cells, suggesting that it may also play a role in regulating other intracellular signaling pathways (4).

Poids moléculaire: Predicted: 47 kDa

Observed: 55 kDa

ID gène: 441925

NCBI Accession: NP_001277622

UniProt: A8MW95