CRH anticorps (AA 30-80)

N° du produit ABIN5689930

L’anticorps Lapin Polyclonal anti-CRH a été validé pour WB, ELISA, IF et IHC (p). Il convient pour détecter CRH dans des échantillons de Humain.

Aperçu rapide pour CRH anticorps (AA 30-80) (ABIN5689930)

Antigène: CRH (Corticotropin Releasing Hormone (CRH))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRH est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CRH anticorps

Épitope: AA 30-80

Specificité: CRH antibody is human specific.

Purification: CRH antibody is affinity chromatography purified via peptide column.

Immunogène: CRH antibody was raised against a 16 amino acid peptide near the amino terminus of human CRH.

The immunogen is located within amino acids 30 - 80 of CRH.

Isotype: IgG

Information d'application

Indications d'application: CRH antibody can be used for detection of CRH by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CRH antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: CRH antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur CRH

Antigène: CRH (Corticotropin Releasing Hormone (CRH))

Autre désignation: CRH

Sujet: Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1). In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2). Marked reduction in this protein has been observed in association with Alzheimer disease (3).

Poids moléculaire: Predicted: 22 kDa

Observed: 29 kDa

ID gène: 1392

NCBI Accession: NP_000747

UniProt: P06850

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour