ERAP1 anticorps (AA 730-780)

N° du produit ABIN5689955

Cet anticorps anti-ERAP1 Polyclonal Lapin (ABIN5689955) détecte spécifiquement ERAP1 dans WB, ELISA, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour ERAP1 anticorps (AA 730-780) (ABIN5689955)

Antigène: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ERAP1 anticorps

Épitope: AA 730-780

Specificité: ERAP1 antibody is human and mouse reactive. At least two isoforms of ERAP1 are known to exist, this antibody will detect both isoforms. ERAP1 antibody is predicted to not cross-react with ERAP2.

Purification: ERAP1 Antibody is affinity chromatography purified via peptide column.

Immunogène: ERAP1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ERAP.

The immunogen is located within amino acids 730 - 780 of ERAP1 .

Isotype: IgG

Information d'application

Indications d'application: ERAP1 antibody can be used for detection of ERAP1 by Western blot at 1 - 2 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ERAP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: ERAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur ERAP1

Antigène: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Autre désignation: ERAP1

Sujet: The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1), a member of the peptidase M1 family, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2). It is also designated as adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1) (3). ERAP1 is localized to the lumen of the ER and induced by interferon. It may be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (3,4).

Poids moléculaire: Predicted: 104 kDa

Observed: 105kDa

ID gène: 51752

NCBI Accession: NP_057526

UniProt: Q9NZ08