IQSEC1 anticorps (AA 60-110)

N° du produit ABIN5690018

Détail du produit anti-IQSEC1 anticorps

Antigène: IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))

Épitope: AA 60-110

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IQSEC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: IQSEC1 antibody is human, mouse and rat reactive. At least four isoforms of IQSEC1 are known to exist. IQSEC1 antibody is predicted to not cross-react with IQSEC2.

Purification: IQSEC1 antibody is affinity chromatography purified via peptide column.

Immunogène: IQSEC1 antibody was raised against a 19 amino acid peptide near the amino terminus of human IQSEC1.

The immunogen is located within amino acids 60 - 110 of IQSEC1.

Isotype: IgG

Information d'application

Indications d'application: IQSEC1 antibody can be used for detection of IQSEC1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry at 2 μ,g/mL. For immunofluorescence start at 2 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IQSEC1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: IQSEC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur IQSEC1

Antigène: IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))

Autre désignation: IQSEC1 (IQSEC1 Produits)

Synonymes: anticorps ARF-GEP100, anticorps ARFGEP100, anticorps BRAG2, anticorps GEP100, anticorps AW561907, anticorps BC026481, anticorps D6Ertd349e, anticorps cI-43, anticorps mKIAA0763, anticorps IQ motif and Sec7 domain 1, anticorps IQSEC1, anticorps Iqsec1

Sujet: ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1). As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis (2,3). IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy (4).

Poids moléculaire: Predicted: 106 kDa

Observed: 103 kDa

ID gène: 9922

NCBI Accession: NP_055684

UniProt: Q6DN90