IQSEC2 anticorps (AA 1380-1430)

N° du produit ABIN5690019

Cet anticorps Lapin Polyclonal détecte spécifiquement IQSEC2 dans ELISA, WB et IHC (p). Il présente une réactivité envers Souris, Humain et Rat.

Aperçu rapide pour IQSEC2 anticorps (AA 1380-1430) (ABIN5690019)

Antigène: IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IQSEC2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-IQSEC2 anticorps

Épitope: AA 1380-1430

Specificité: IQSEC2 antibody is human, mouse and rat reactive. At least two isoforms of IQSEC2 are known to exist, this antibody will only detect the larger isoform. IQSEC2 antibody is predicted to not cross-react with IQSEC1.

Purification: IQSEC2 antibody is affinity chromatography purified via peptide column.

Immunogène: IQSEC2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IQSEC2.

The immunogen is located within amino acids 1380 - 1430 of IQSEC2.

Isotype: IgG

Information d'application

Indications d'application: IQSEC2 antibody can be used for detection of IQSEC2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IQSEC2 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: IQSEC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur IQSEC2

Antigène: IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))

Autre désignation: IQSEC2

Sujet: ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. Similar to the related protein IQSEC1, IQSEC2 is a guanine nucleotide exchange protein for ARF1 and ARF6 that belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1,2). IQSEC2 is a major component of the postsynaptic density (PSD) and colocalizes with PSD-95. It has been suggested to modulate the functions of the ARF proteins (1). Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation (3).

Poids moléculaire: Predicted: 104, 133, 141, 164 kDa

Observed: 140 kDa

ID gène: 23096

NCBI Accession: NP_001104595

UniProt: Q5JU85