Vinculin anticorps (AA 1060-1110)

N° du produit ABIN5690319

Cet anticorps Lapin Polyclonal détecte spécifiquement Vinculin dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Vinculin anticorps (AA 1060-1110) (ABIN5690319)

Antigène: Vinculin (VCL)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Vinculin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Vinculin anticorps

Épitope: AA 1060-1110

Specificité: Vinculin antibody is human, mouse and rat specific. At least three isoforms of Vinculin are known to exist.

Purification: Vinculin Antibody is affinity chromatography purified via peptide column.

Immunogène: Vinculin antibody was raised against a 16 amino acid peptide near the carboxy terminus of human Vinculin.

The immunogen is located within amino acids 1060 - 1110 of Vinculin .

Isotype: IgG

Information d'application

Indications d'application: Vinculin antibody can be used for detection of Vinculin by Western blot at 1 - 2 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Vinculin Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Vinculin antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur Vinculin

Antigène: Vinculin (VCL)

Autre désignation: Vinculin

Sujet: Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1). Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2). Expression of vinculin were shown to be affected by the level of actin expression (2,3). Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4). Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5).

Poids moléculaire: Predicted: 117 kDa

Observed: 120kDa

ID gène: 7414

NCBI Accession: NP_003364

UniProt: P18206

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2