BTLA anticorps

N° du produit ABIN5690631

Cet anticorps Rat Monoclonal détecte spécifiquement BTLA dans FACS, ELISA et Func. Il présente une réactivité envers Humain.

Aperçu rapide pour BTLA anticorps (ABIN5690631)

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp BTLA est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Functional Studies (Func)

Clone: 6F4

Détail du produit anti-BTLA anticorps

Specificité: Recognizes human BTLA.

Pureté: > 95% (SDS-PAGE)

Immunogène: Ectodomain of human BTLA fused to human IgG Fc.

Isotype: IgG1

Information d'application

Indications d'application: Immunohistochemistry: (frozen sections).

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In PBS containing 10 % glycerol.

Stock: -20 °C

Stockage commentaire: Stable for at least 1 year after receipt when stored at -20°C.

Détails sur BTLA

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Autre désignation: BTLA

Sujet: B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.

ID gène: 151888

NCBI Accession: NP_861445

UniProt: Q7Z6A9

Pathways: Cancer Immune Checkpoints