Arylsulfatase A anticorps (C-Term) (DyLight 488)

N° du produit ABIN5692788

Cet anticorps Souris Monoclonal détecte spécifiquement Arylsulfatase A dans FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour Arylsulfatase A anticorps (C-Term) (DyLight 488) (ABIN5692788)

Antigène: Arylsulfatase A (ARSA)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Arylsulfatase A est conjugé à/à la DyLight 488

Application: Flow Cytometry (FACS)

Clone: 4C10

Détail du produit anti-Arylsulfatase A anticorps (DyLight 488)

Épitope: AA 454-482, C-Term

Fonction: Anti-Human ARSA DyLight® 488 conjugated Antibody(monoclonal, 4C10)

Séquence: QALKQLQLLK AQLDAAVTFG PSQVARGED

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Human ARSA DyLight® 488 conjugated Antibody (monoclonal, 4C10) (ABIN5692787)-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human ARSA, different from the related mouse sequence by six amino acids.

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Fujii T, Kobayashi T, Honke K et al. (1992). "Proteolytic processing of human lysosomal arylsulfatase A". Biochim. Biophys. Acta 1122 (1): 93-8. 2. Kondo R, Wakamatsu N, Yoshino H et al. (1991)."Identification of a mutation in the arylsulfatase A gene of a patient with adult-type metachromatic leukodystrophy". Am. J. Hum. Genet. 48 (5): 971-8. 3. Matzner U, Herbst E, Hedayati KK, Lüllmann-Rauch R, Wessig C, Schröder S, Eistrup C, Möller C, Fogh J, Gieselmann V (May 2005). "Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy". Hum. Mol. Genet. 14 (9): 1139-52.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Détails sur Arylsulfatase A

Antigène: Arylsulfatase A (ARSA)

Autre désignation: ARSA

Sujet:

Synonyms: Arylsulfatase A, ASA, Cerebroside-sulfatase, Arylsulfatase A component B, Arylsulfatase A component C, ARSA

Background: Arylsulfatase A (ARSA) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate intocerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene. ARSA is mapped to 22q13.33. The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.

Poids moléculaire: 39 kDa

ID gène: 410

UniProt: P15289