ICOS anticorps (AA 21-140)

N° du produit ABIN5693002

L’anticorps Lapin Polyclonal anti-ICOS a été validé pour IHC, FACS, ELISA et ICC. Il convient pour détecter ICOS dans des échantillons de Humain.

Aperçu rapide pour ICOS anticorps (AA 21-140) (ABIN5693002)

Antigène: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ICOS est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-ICOS anticorps

Épitope: AA 21-140

Fonction: Anti-ICOS Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-ICOS Antibody Picoband® (ABIN5693002). Tested in ELISA, Flow Cytometry, IHC, ICC applications. This antibody reacts with Human.

Immunogène: E. coli-derived human ICOS recombinant protein (Position: E21-K140).

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
Immunocytochemistry, 0.5-1 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells
ELISA, 0.1-0.5 μg/mL
1. Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, Kroczek RA (Jan 1999). "ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28". Nature. 397(6716): 263-6. 2. Rudd CE, Schneider H (Jul 2003). "Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling". Nature Reviews. Immunology. 3 (7): 544-56.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur ICOS

Antigène: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Autre désignation: ICOS

Sujet:

Synonyms: Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, ICOS, AILIM

Tissue Specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.

Background: Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene. The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.

Poids moléculaire: 20 kDa

ID gène: 29851

UniProt: Q9Y6W8

Pathways: Cancer Immune Checkpoints