PI3 anticorps (AA 61-117)

N° du produit ABIN5693295

Cet anticorps Souris Monoclonal détecte spécifiquement PI3 dans IHC et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour PI3 anticorps (AA 61-117) (ABIN5693295)

Antigène: PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PI3 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Clone: C7

Détail du produit anti-PI3 anticorps

Épitope: AA 61-117

Fonction: Anti-Elafin/Skalp PI3 Antibody (monoclonal, C7)

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Elafin/Skalp PI3 Antibody Picoband® (monoclonal, C7) (ABIN5693295). Tested in ELISA, IHC applications. This antibody reacts with Human.

Immunogène: E. coli-derived human Elafin/Skalp recombinant protein (Position: A61-Q117).

Isotype: IgG1

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
ELISA (Cap), 1-5 μg/mL1. "Entrez Gene: PI3 peptidase inhibitor 3, skin-derived (SKALP)". 2. Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J 368 (Pt 1): 233-42. 3. Molhuizen HO, Zeeuwen PL, Olde Weghuis D, Geurts van Kessel A, Schalkwijk J (Feb 1994). "Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12→q13". Cytogenet Cell Genet 66 (2): 129-31.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur PI3

Antigène: PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))

Autre désignation: PI3

Sujet:

Synonyms: Elafin, Elastase-specific inhibitor, ESI, Peptidase inhibitor 3, PI-3, Protease inhibitor WAP3, Skin-derived antileukoproteinase, SKALP, WAP four-disulfide core domain protein 14, PI3, WAP3, WFDC14

Tissue Specificity: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.

Background: Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene. This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. And this gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.

Poids moléculaire: 25 kDa

ID gène: 5266

UniProt: P19957