DPYD anticorps (AA 356-511)

N° du produit ABIN5693320

Détail du produit anti-DPYD anticorps

Antigène: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Épitope: AA 356-511

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DPYD est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for DPYD detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.

Immunogène: E. coli-derived human DPYD recombinant protein (Position: A356-Y511).

Information d'application

Indications d'application:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Application Details: Western blot, 0.1-0.5 μg/mL
Direct ELISA, 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Détails sur DPYD

Antigène: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Autre désignation: DPYD (DPYD Produits)

Synonymes: anticorps DPYD, anticorps dpyd, anticorps zgc:77205, anticorps AI315208, anticorps DPD, anticorps E330028L06Rik, anticorps DHP, anticorps DHPDHASE, anticorps dhp, anticorps dhpdhase, anticorps dpd, anticorps 14.t00017, anticorps DDBDRAFT_0189681, anticorps DDBDRAFT_0231100, anticorps DDB_0189681, anticorps DDB_0231100, anticorps dpyda, anticorps zgc:153505, anticorps dihydropyrimidine dehydrogenase, anticorps dihydropyrimidine dehydrogenase b, anticorps dihydropyrimidine dehydrogenase L homeolog, anticorps dihydropyrimidine dehydrogenase [NADP(+)], anticorps dihydropyrimidine dehydrogenase a, tandem duplicate 1, anticorps DPYD, anticorps Dpyd, anticorps dpydb, anticorps dpyd.L, anticorps EHI_012980, anticorps LOC5573038, anticorps EDI_044620, anticorps pyd1, anticorps dpyda.1

Sujet:

Synonyms: Dihydropyrimidine dehydrogenase [NADP(+)], DHPDHase, DPD, Dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, DPYD

Tissue Specificity: Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.

Background: DPYD (Dihydropyrimidine Dehydrogenase), also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the DPYD gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the DPYD gene is mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the DPYD gene is mapped to 1p22. The highest level of DPD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.

UniProt: Q12882

Pathways: Ribonucleoside Biosynthetic Process