ABAT anticorps

N° du produit ABIN5699780

L’anticorps Lapin Polyclonal anti-ABAT a été validé pour WB, IHC, ELISA et IP. Il convient pour détecter ABAT dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ABAT anticorps (ABIN5699780)

Antigène: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABAT est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Détail du produit anti-ABAT anticorps

Fonction: ABAT antibody

Immunogène: 4-aminobutyrate aminotransferase

Isotype: IgG

Information d'application

Indications d'application: WB : 1:200-1:2000,IHC:1:20-1:200,IP:1:200-1:2000

Commentaires:

human liver tissue were subjected to SDS PAGE followed by western blot with FNab00026(ABAT antibody) at dilution of 1:300

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ABAT

Antigène: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Autre désignation: ABAT

Sujet:

Synonyms: 4-aminobutyrate aminotransferase, mitochondrial|(S)-3-amino-2-methylpropionate transaminase|GABA aminotransferase (GABA-AT)|Gamma-amino-N-butyrate transaminase (GABA transaminase, GABA-T)|L-AIBAT|ABAT|GABAT

Background: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95 % similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Poids moléculaire: 55kDa

ID gène: 18

UniProt: P80404

Pathways: Monocarboxylic Acid Catabolic Process