2B4 anticorps

N° du produit ABIN5700466

Cet anticorps Lapin Polyclonal détecte spécifiquement 2B4 dans ELISA et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour 2B4 anticorps (ABIN5700466)

Antigène: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp 2B4 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-2B4 anticorps

Fonction: CD244 antibody

Immunogène: CD244 molecule, natural killer cell receptor 2B4

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur 2B4

Antigène: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Autre désignation: CD244

Sujet:

Synonyms: Natural killer cell receptor 2B4|NK cell activation-inducing ligand (NAIL)|NK cell type I receptor protein 2B4 (NKR2B4, h2B4)|SLAM family member 4 (SLAMF4)|Signaling lymphocytic activation molecule 4|CD244|2B4

Background: Heterophilic receptor of the signaling lymphocytic activation molecule(SLAM) family, its ligand is CD48. SLAM receptors triggered by homo-or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer(NK) cell receptor(PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN(PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2(PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis(PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells(By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1(PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells(PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation, expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells(By similarity). Inhibits inflammatory responses in dendritic cells(DCs)(By similarity).

ID gène: 51744

UniProt: Q9BZW8