BHLHE41 anticorps

N° du produit ABIN5702192

L’anticorps Lapin Polyclonal anti-BHLHE41 a été validé pour WB, ELISA et IP. Il convient pour détecter BHLHE41 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BHLHE41 anticorps (ABIN5702192)

Antigène: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BHLHE41 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Détail du produit anti-BHLHE41 anticorps

Fonction: BHLHE41 antibody

Immunogène:

Immunogen sequence: 419-482

Immunogen: basic helix-loop-helix family, member e41

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur BHLHE41

Antigène: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Autre désignation: BHLHE41

Sujet:

Synonyms: Class E basic helix-loop-helix protein 41 (bHLHe41)|Class B basic helix-loop-helix protein 3 (bHLHb3)|Differentially expressed in chondrocytes protein 2 (hDEC2)|Enhancer-of-split and hairy-related protein 1 (SHARP-1)|BHLHE41|BHLHB3|DEC2|SHARP1

Background: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop(DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors(PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements(5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

Poids moléculaire: 51 kDa,75 kDa

ID gène: 79365

UniProt: Q9C0J9

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development