IFIH1 anticorps (AA 1-210)

N° du produit ABIN5703110

L’anticorps anti-IFIH1 Polyclonal Lapin est utilisé pour la détection de IFIH1 dans des échantillons de Humain. Il a été validé pour WB, ELISA et IP.

Aperçu rapide pour IFIH1 anticorps (AA 1-210) (ABIN5703110)

Antigène: IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFIH1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Détail du produit anti-IFIH1 anticorps

Épitope: AA 1-210

Fonction: IFIH1 antibody

Immunogène:

Immunogen sequence: 1-210aa

Immunogen: interferon induced with helicase C domain 1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur IFIH1

Antigène: IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

Autre désignation: IFIH1

Sujet:

Synonyms: Interferon-induced helicase C domain-containing protein 1|Clinically amyopathic dermatomyositis autoantigen 140 kDa (CADM-140 autoantigen)|Helicase with 2 CARD domains (Helicard)|Interferon-induced with helicase C domain protein 1|Melanoma differentiation-associated protein 5 (MDA-5)|Murabutide down-regulated protein|RIG-I-like receptor 2 (RLR-2)|RNA helicase-DEAD box protein 116|IFIH1|MDA5|RH116

Background: Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA(>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein(MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons(IFNs), IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus(EMCV) and mengo encephalomyocarditis virus(ENMG). Can also detect other viruses such as dengue virus(DENV), west Nile virus(WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L(RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

Poids moléculaire: 117-125 kDa

ID gène: 64135

UniProt: Q9BYX4

Pathways: Activation of Innate immune Response