Keratin 10 anticorps

N° du produit ABIN5707747

Cet anticorps anti-Keratin 10 est un anticorps Lapin Monoclonal détectant Keratin 10 dans IHC (p). Adapté pour Humain.

Aperçu rapide pour Keratin 10 anticorps (ABIN5707747)

Antigène: Keratin 10 (KRT10)

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Keratin 10 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: KRT10-1948R

Détail du produit anti-Keratin 10 anticorps

Purification: Purified

Pureté: Protein A affinity chromatography

Immunogène: A cytoskeletal preparation extracted from human ectocervical epithelium was used as the immunogen for the recombinant CK10 antibody.

Isotype: IgG kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant CK10 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.1-0.2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant CK10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Keratin 10

Antigène: Keratin 10 (KRT10)

Autre désignation: KRT10 / Cytokeratin 10

Sujet: This mAb recognizes a protein of 56.5  kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation, it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.