Recombinant Filaggrin anticorps (AA 198-288)

N° du produit ABIN5707857

L’anticorps anti-Filaggrin Monoclonal Lapin est utilisé pour la détection de Filaggrin dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant Filaggrin anticorps (AA 198-288) (ABIN5707857)

Antigène: Filaggrin (FLG)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Filaggrin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: FLG-1957R

Détail du produit anti-Filaggrin anticorps

Épitope: AA 198-288

Fonction: Recombinant FLG Antibody / Filaggrin

Purification: Protein G affinity chromatography

Immunogène: Amino acids 198-288 of human Filaggrin were used as the immunogen for this recombinant FLG antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant FLG antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant FLG antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Filaggrin

Antigène: Filaggrin (FLG)

Autre désignation: FLG

Sujet: Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

UniProt: P20930

Pathways: Sensory Perception of Sound, Stem Cell Maintenance