MAML3 anticorps (full length)

N° du produit ABIN5707997

Cet anticorps Souris Monoclonal détecte spécifiquement MAML3 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour MAML3 anticorps (full length) (ABIN5707997)

Antigène: MAML3 (Mastermind-Like 3 (MAML3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAML3 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: MAML3-1303

Détail du produit anti-MAML3 anticorps

Épitope: full length

Fonction: MAML3 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A human full length recombinant protein was used as the immunogen for this MAML3 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MAML3 antibody to be titered up or down for optimal performance.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the MAML3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur MAML3

Antigène: MAML3 (Mastermind-Like 3 (MAML3))

Autre désignation: MAML3

Sujet: Mastermind-like 3 is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch 1-4 proteins. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Ji°, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, its upregulation is thought to be involved in oncogenesis.