ICT1 anticorps (AA 30-206)

N° du produit ABIN5775998

Cet anticorps anti-ICT1 est un anticorps Souris Monoclonal détectant ICT1 dans WB, ELISA et FACS. Adapté pour Humain.

Aperçu rapide pour ICT1 anticorps (AA 30-206) (ABIN5775998)

Antigène: ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ICT1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: AT1E9

Détail du produit anti-ICT1 anticorps

Épitope: AA 30-206

Fonction: Human ICT1 antibody

Purification: Purified

Immunogène: Recombinant human ICT1 (30-206aa) purified from E. coli

Isotype: IgG1 kappa

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Détails sur ICT1

Antigène: ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

Autre désignation: ICT1

Sujet: Peptidyl-tRNA hydrolase ICT1 acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. This neoplastic-induced deviation is marked by a change in expression of several mRNAs. ICT1 is a member of the prokaryotic/mitochondrial release factor family whose expression is downregulated over 4 fold upon colon stem cell differentiation. This downregulation of ICT1 could lead to its use as a marker for detection of colon carcinomas.

NCBI Accession: NP_001536