RAS anticorps (AA 1-186)

N° du produit ABIN5776161

Cet anticorps Souris Monoclonal détecte spécifiquement RAS dans WB, ELISA, IF et ICC. Il présente une réactivité envers Humain.

Aperçu rapide pour RAS anticorps (AA 1-186) (ABIN5776161)

Antigène: RAS

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RAS est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: AT2F8

Détail du produit anti-RAS anticorps

Épitope: AA 1-186

Immunogène: Recombinant human KRAS (1-186aa) purified from E. coli

Isotype: IgG2b kappa

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Détails sur RAS

Antigène: RAS

Autre désignation: Ras

Sujet: All RAS protein family members belong to a class of protein called small GTPase, and are involved cellular signal transduction. RAS is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. Mutations in RAS genes can lead to the production of permanently activated RAS proteins. This can cause unintended and overactive signaling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive RAS signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRas, KRas, NRas) are the most common oncogenes in human cancer, mutations that permanently activate RAS are found in 20 % to 25 % of all human tumors and up to 90 % in certain types of cancer. RAS inhibitors are being studied as a treatment for cancer, and other diseases with RAS overexpression.

NCBI Accession: NP_203524