Ataxin 1 anticorps (AA 586-815)

N° du produit ABIN6137363

Cet anticorps anti-Ataxin 1 est un anticorps Lapin Polyclonal détectant Ataxin 1 dans WB. Adapté pour Humain.

Aperçu rapide pour Ataxin 1 anticorps (AA 586-815) (ABIN6137363)

Antigène: Ataxin 1 (ATXN1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ataxin 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Ataxin 1 anticorps

Épitope: AA 586-815

Séquence: ELKKVEDLKT EDFIQSAEIS NDLKIDSSTV ERIEDSHSPG VAVIQFAVGE HRAQVSVEVL VEYPFFVFGQ GWSSCCPERT SQLFDLPCSK LSVGDVCISL TLKNLKNGSV KKGQPVDPAS VLLKHSKADG LAGSRHRYAE QENGINQGSA QMLSENGELK FPEKMGLPAA PFLTKIEPSK PAATRKRRWS APESRKLEKS EDEPPLTLPK PSLIPQEVKI CIEGRSNVGK

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 586-815 of human ATXN1 (NP_001121636.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Ataxin 1

Antigène: Ataxin 1 (ATXN1)

Autre désignation: ATXN1

Sujet: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.,ATXN1,ATX1,D6S504E,SCA1,ataxin-1,Epigenetics & Nuclear Signaling,Signal Transduction,PI3K-Akt Signaling Pathway,Neuroscience,Neurodegenerative Diseases,ATXN1

Poids moléculaire: 86 kDa

ID gène: 6310

UniProt: P54253

Pathways: Synaptic Membrane