CNOT1 anticorps (AA 2137-2376)

N° du produit ABIN6138777

Détail du produit anti-CNOT1 anticorps

Antigène: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Épitope: AA 2137-2376

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CNOT1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: PRNMRLPDPF TPNLKVDMLS EINIAPRILT NFTGVMPPQF KKDLDSYLKT RSPVTFLSDL RSNLQVSNEP GNRYNLQLIN ALVLYVGTQA IAHIHNKGST PSMSTITHSA HMDIFQNLAV DLDTEGRYLF LNAIANQLRY PNSHTHYFSC TMLYLFAEAN TEAIQEQITR VLLERLIVNR PHPWGLLITF IELIKNPAFK FWNHEFVHCA PEIEKLFQSV AQCCMGQKQA QQVMEGTGAS

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 2137-2376 of human CNOT1 (NP_057368.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CNOT1

Antigène: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Autre désignation: CNOT1 (CNOT1 Produits)

Synonymes: anticorps CDC39, anticorps NOT1, anticorps NOT1H, anticorps 6030411K04Rik, anticorps AA815922, anticorps D830048B13, anticorps RGD1308009, anticorps GB18988, anticorps cdc39-like, anticorps im:7141761, anticorps kiaa1007l, anticorps wu:fc58h04, anticorps zgc:152902, anticorps CNOT1, anticorps not1, anticorps cdc39, anticorps not1h, anticorps ad-005, anticorps NV18106, anticorps CCR4-NOT transcription complex subunit 1, anticorps CCR4-NOT transcription complex, subunit 1, anticorps CNOT1, anticorps Cnot1, anticorps LOC412371, anticorps cnot1, anticorps LOC100114396

Sujet: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES cell identity.,CNOT1,AD-005,CDC39,NOT1,NOT1H,Epigenetics & Nuclear Signaling,RNA Binding,CNOT1

Poids moléculaire: 173 kDa/241 kDa/266 kDa

ID gène: 23019

UniProt: A5YKK6

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance