CPT1A anticorps (AA 497-756)

N° du produit ABIN6138976

L’anticorps Lapin Polyclonal anti-CPT1A a été validé pour WB, IP et IF. Il convient pour détecter CPT1A dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour CPT1A anticorps (AA 497-756) (ABIN6138976)

Antigène: CPT1A (Carnitine Palmitoyltransferase 1A (Liver) (CPT1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CPT1A est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-CPT1A anticorps

Épitope: AA 497-756

Séquence: GYAEDGHCKG DINPNIPYPT RLQWDIPGEC QEVIETSLNT ANLLANDVDF HSFPFVAFGK GIIKKCRTSP DAFVQLALQL AHYKDMGKFC LTYEASMTRL FREGRTETVR SCTTESCDFV RAMVDPAQTV EQRLKLFKLA SEKHQHMYRL AMTGSGIDRH LFCLYVVSKY LAVESPFLKE VLSEPWRLST SQTPQQQVEL FDLENNPEYV SSGGGFGPVA DDGYGVSYIL VGENLINFHI SSKFSCPETG IISQGPSSDT

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 497-756 of human CPT1A (NP_001027017.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:100

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-CPT1A (ABIN6138976)

Yang, He, Yao, Tan, Zhu, Li, Guo, Wei: "Regulation of AMPK-related glycolipid metabolism imbalances redox homeostasis and inhibits anchorage independent growth in human breast cancer cells." dans: Redox biology, Vol. 17, pp. 180-191, (2018) (PubMed).

Ni, He, Dai, Yao, Guo, Wei: "Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism." dans: Cell death & disease, Vol. 8, Issue 6, pp. e2865, (2018) (PubMed).

Détails sur CPT1A

Antigène: CPT1A (Carnitine Palmitoyltransferase 1A (Liver) (CPT1A))

Autre désignation: CPT1A

Sujet: The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,CPT1A,CPT1,CPT1-L,L-CPT1,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Lipid Metabolism,AMPK Signaling Pathway,Endocrine and metabolic diseases,Obesity,Cardiovascular,Lipids,Fatty Acids,CPT1A

Poids moléculaire: 86 kDa/88 kDa

ID gène: 1374

UniProt: P50416

Pathways: AMPK Signaling, Regulation of Lipid Metabolism by PPARalpha, Feeding Behaviour, Monocarboxylic Acid Catabolic Process