DHX58 anticorps (AA 389-678)

N° du produit ABIN6139609

Cet anticorps Lapin Polyclonal détecte spécifiquement DHX58 dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour DHX58 anticorps (AA 389-678) (ABIN6139609)

Antigène: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DHX58 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-DHX58 anticorps

Épitope: AA 389-678

Séquence: QQQGLQTVDI RAQLLIGAGN SSQSTHMTQR DQQEVIQKFQ DGTLNLLVAT SVAEEGLDIP HCNVVVRYGL LTNEISMVQA RGRARADQSV YAFVATEGSR ELKRELINEA LETLMEQAVA AVQKMDQAEY QAKIRDLQQA ALTKRAAQAA QRENQRQQFP VEHVQLLCIN CMVAVGHGSD LRKVEGTHHV NVNPNFSNYY NVSRDPVVIN KVFKDWKPGG VISCRNCGEV WGLQMIYKSV KLPVLKVRSM LLETPQGRIQ AKKWSRVPFS VPDFDFLQHC AENLSDLSLD

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 389-678 of human DHX58 (NP_077024.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur DHX58

Antigène: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Autre désignation: DHX58

Sujet: Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3. Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.,DHX58,D11LGP2,D11lgp2e,LGP2,RLR-3,Epigenetics & Nuclear Signaling,Immunology & Inflammation,DHX58

Poids moléculaire: 76 kDa

ID gène: 79132

UniProt: Q96C10