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DLAT anticorps (AA 1-290)

DLAT Reactivité: Humain WB, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6139639
  • Antigène Voir toutes DLAT Anticorps
    DLAT (Dihydrolipoyl Transacetylase (DLAT))
    Épitope
    • 8
    • 8
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-290
    Reactivité
    • 58
    • 20
    • 17
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 54
    • 7
    Lapin
    Clonalité
    • 54
    • 7
    Polyclonal
    Conjugué
    • 32
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp DLAT est non-conjugé
    Application
    • 43
    • 25
    • 23
    • 13
    • 9
    • 9
    • 7
    • 5
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Séquence
    MWRVCARRAQ NVAPWAGLEA RWTALQEVPG TPRVTSRSGP APARRNSVTT GYGGVRALCG WTPSSGATPR NRLLLQLLGS PGRRYYSLPP HQKVPLPSLS PTMQAGTIAR WEKKEGDKIN EGDLIAEVET DKATVGFESL EECYMAKILV AEGTRDVPIG AIICITVGKP EDIEAFKNYT LDSSAAPTPQ AAPAPTPAAT ASPPTPSAQA PGSSYPPHMQ VLLPALSPTM TMGTVQRWEK KVGEKLSEGD LLAEIETDKA TIGFEVQEEG YLAKILVPEG TRDVPLGTPL
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human DLAT (NP_001922.2).
    Isotype
    IgG
    Top Product
    Discover our top product DLAT Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000,IF,1:20 - 1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    DLAT (Dihydrolipoyl Transacetylase (DLAT))
    Autre désignation
    DLAT (DLAT Produits)
    Synonymes
    anticorps DLAT, anticorps Dmel\\CG5261, anticorps EP(2)0816, anticorps EP816, anticorps anon-WO0118547.121, anticorps DLTA, anticorps PDC-E2, anticorps PDCE2, anticorps wu:fc14f10, anticorps wu:fc21f08, anticorps wu:fc86g11, anticorps wu:fj57d06, anticorps 6332404G05Rik, anticorps midline uncoordinated, anticorps dihydrolipoamide S-acetyltransferase L homeolog, anticorps dihydrolipoamide S-acetyltransferase, anticorps dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex), anticorps muc, anticorps dlat.L, anticorps DLAT, anticorps Dlat, anticorps dlat
    Sujet
    This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.,DLAT,DLTA,PDC-E2,PDCE2,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Carbohydrate metabolism,DLAT
    Poids moléculaire
    68 kDa
    ID gène
    1737
    UniProt
    P10515
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