GLP1R anticorps (AA 22-116)

N° du produit ABIN6141138

Détail du produit anti-GLP1R anticorps

Antigène: GLP1R (Glucagon-Like Peptide 1 Receptor (GLP1R))

Épitope: AA 22-116

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLP1R est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: GPRPQGATVS LWETVQKWRE YRRQCQRSLT EDPPPATDLF CNRTFDEYAC WPDGEPGSFV NVSCPWYLPW ASSVPQGHVY RFCTAEGLWL QKDNS

Réactivité croisée: Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 22-116 of human GLP1R (NP_002053.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-GLP1R (ABIN6141138)

Gao, Li, Li: "Exendin-4 promotes the osteogenic differentiation of osteoblasts via the Hedgehog/Gli1 signaling pathway." dans: American journal of translational research, Vol. 10, Issue 1, pp. 315-324, (2018) (PubMed).

Détails sur GLP1R

Antigène: GLP1R (Glucagon-Like Peptide 1 Receptor (GLP1R))

Autre désignation: GLP1R (GLP1R Produits)

Synonymes: anticorps GLP1R, anticorps LOC100228311, anticorps GLP-1R, anticorps GLP1Rc, anticorps Glip, anticorps RATGL1RCP, anticorps glucagon like peptide 1 receptor, anticorps glucagon-like peptide 1 receptor, anticorps GLP1R, anticorps Glp1r

Sujet: This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.,GLP1R,GLP-1,GLP-1-R,GLP-1R,Cancer,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Endocrine & Metabolism,Endocrine and metabolic diseases,Diabetes,Neuroscience,Cardiovascular,GLP1R

Poids moléculaire: 53 kDa

ID gène: 2740

UniProt: P43220

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, cAMP Metabolic Process, Feeding Behaviour