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LAMC2 anticorps (AA 862-1111)

LAMC2 Reactivité: Humain WB, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6143076
  • Antigène Voir toutes LAMC2 Anticorps
    LAMC2 (Laminin, gamma 2 (LAMC2))
    Épitope
    • 8
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 862-1111
    Reactivité
    • 28
    • 24
    • 8
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 45
    • 3
    Lapin
    Clonalité
    • 46
    • 2
    Polyclonal
    Conjugué
    • 23
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LAMC2 est non-conjugé
    Application
    • 37
    • 22
    • 12
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Séquence
    SDQSFQVEEA KRIKQKADSL SSLVTRHMDE FKRTQKNLGN WKEEAQQLLQ NGKSGREKSD QLLSRANLAK SRAQEALSMG NATFYEVESI LKNLREFDLQ VDNRKAEAEE AMKRLSYISQ KVSDASDKTQ QAERALGSAA ADAQRAKNGA GEALEISSEI EQEIGSLNLE ANVTADGALA MEKGLASLKS EMREVEGELE RKELEFDTNM DAVQMVITEA QKVDTRAKNA GVTIQDTLNT LDGLLHLMGM
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 862-1111 of human LAMC2 (NP_061486.2).
    Isotype
    IgG
    Top Product
    Discover our top product LAMC2 Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000,IF,1:50 - 1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    LAMC2 (Laminin, gamma 2 (LAMC2))
    Autre désignation
    LAMC2 (LAMC2 Produits)
    Synonymes
    anticorps LAMC2, anticorps B2T, anticorps BM600, anticorps CSF, anticorps EBR2, anticorps EBR2A, anticorps LAMB2T, anticorps LAMNB2, anticorps AA589349, anticorps laminin subunit gamma 2, anticorps laminin, gamma 2, anticorps LAMC2, anticorps Lamc2
    Sujet
    This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain, however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.,LAMC2,B2T,BM600,CSF,EBR2,EBR2A,LAMB2T,LAMNB2,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Neuroscience,LAMC2
    Poids moléculaire
    121 kDa/130 kDa
    ID gène
    3918
    UniProt
    Q13753
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