MORF4L1 anticorps (AA 1-100)

N° du produit ABIN6143948

L’anticorps anti-MORF4L1 Polyclonal Lapin est utilisé pour la détection de MORF4L1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour MORF4L1 anticorps (AA 1-100) (ABIN6143948)

Antigène: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MORF4L1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MORF4L1 anticorps

Épitope: AA 1-100

Séquence: MAPKQDPKPK FQEGERVLCF HGPLLYEAKC VKVAIKDKQV KYFIHYSGWN KNWDEWVPES RVLKYVDTNL QKQRELQKAN QEQYAEGKMR GAAPGKKTSG

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human MORF4L1 (NP_006782.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MORF4L1

Antigène: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Autre désignation: MORF4L1

Sujet: Component of the NuA4 histone acetyltransferase (HAT complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR and resistance to mitomycin C (MMC. Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.,MORF4L1,Eaf3,FWP006,HsT17725,MEAF3,MORFRG15,MRG15,S863-6,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,MORF4L1

Poids moléculaire: 26 kDa/37 kDa/41 kDa

ID gène: 10933

UniProt: Q9UBU8

Pathways: Chromatin Binding