NAA50 anticorps (AA 1-169)

N° du produit ABIN6144327

L’anticorps Lapin Polyclonal anti-NAA50 a été validé pour WB et IF. Il convient pour détecter NAA50 dans des échantillons de Humain.

Aperçu rapide pour NAA50 anticorps (AA 1-169) (ABIN6144327)

Antigène: NAA50 (N(alpha)-Acetyltransferase 50, NatE Catalytic Subunit (NAA50))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NAA50 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-NAA50 anticorps

Épitope: AA 1-169

Séquence: MKGSRIELGD VTPHNIKQLK RLNQVIFPVS YNDKFYKDVL EVGELAKLAY FNDIAVGAVC CRVDHSQNQK RLYIMTLGCL APYRRLGIGT KMLNHVLNIC EKDGTFDNIY LHVQISNESA IDFYRKFGFE IIETKKNYYK RIEPADAHVL QKNLKVPSGQ NADVQKTDN

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-169 of human NAA50 (NP_079422.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NAA50

Antigène: NAA50 (N(alpha)-Acetyltransferase 50, NatE Catalytic Subunit (NAA50))

Autre désignation: NAA50

Sujet: N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity. Does not influence the acetyltransferase activity of NAA10. However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex. The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides. Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10.,NAA50,MAK3,NAT13,NAT13P,NAT5,NAT5P,SAN,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,NAA50

Poids moléculaire: 9 kDa/19 kDa

ID gène: 80218

UniProt: Q9GZZ1