PPP1R12A anticorps (AA 710-970)

N° du produit ABIN6146060

Cet anticorps anti-PPP1R12A est un anticorps Lapin Polyclonal détectant PPP1R12A dans WB et IHC. Adapté pour Humain.

Aperçu rapide pour PPP1R12A anticorps (AA 710-970) (ABIN6146060)

Antigène: PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP1R12A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PPP1R12A anticorps

Épitope: AA 710-970

Séquence: TIGRSRSTRT REQENEEKEK EEKEKQDKEK QEEKKESETS REDEYKQKYS RTYDETYQRY RPVSTSSSTT PSSSLSTMSS SLYASSQLNR PNSLVGITSA YSRGITKENE REGEKREEEK EGEDKSQPKS IRERRRPREK RRSTGVSFWT QDSDENEQEQ QSDTEEGSNK KETQTDSISR YETSSTSAGD RYDSLLGRSG SYSYLEERKP YSSRLEKDDS TDFKKLYEQI LAENEKLKAQ LHDTNMELTD LKLQLEKATQ R

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 710-970 of human PPP1R12A (NP_002471.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PPP1R12A

Antigène: PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Autre désignation: PPP1R12A

Sujet: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.,PPP1R12A,M130,MBS,MYPT1,MYPT1,Epigenetics & Nuclear Signaling,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Cell Cycle,Cytoskeleton,Motor Proteins,Actins,PPP1R12A

Poids moléculaire: 105 kDa/109 kDa/111 kDa/115 kDa

ID gène: 4659

UniProt: O14974

Pathways: M Phase