PRDM6 anticorps (AA 376-595)

N° du produit ABIN6146147

Détail du produit anti-PRDM6 anticorps

Antigène: PRDM6 (PR Domain Containing 6 (PRDM6))

Épitope: AA 376-595

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRDM6 est non-conjugé

Application: Western Blotting (WB)

Séquence: LQCIAQDENL NVPSTVMEAM CRQDALQPFN KSSKLAPTTQ QRSVVFPQTP CSRNFSLLDK SGPIESGFNQ INVKNQRVLA SPTSTSQLHS EFSDWHLWKC GQCFKTFTQR ILLQMHVCTQ NPDRPYQCGH CSQSFSQPSE LRNHVVTHSS DRPFKCGYCG RAFAGATTLN NHIRTHTGEK PFKCERCERS FTQATQLSRH QRMPNECKPI TESPESIEVD

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 376-595 of human PRDM6 (NP_001129711.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PRDM6

Antigène: PRDM6 (PR Domain Containing 6 (PRDM6))

Autre désignation: PRDM6 (PRDM6 Produits)

Synonymes: anticorps Gm92, anticorps PRISM, anticorps RGD1559594, anticorps PRDM6, anticorps PR/SET domain 6, anticorps PR domain containing 6, anticorps putative histone-lysine N-methyltransferase PRDM6, anticorps PRDM6, anticorps Prdm6, anticorps LOC100354345, anticorps prdm6

Sujet: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.,PRDM6,KMT8C,PDA3,PRISM,Epigenetics & Nuclear Signaling,PRDM6

Poids moléculaire: 14 kDa/46 kDa/64 kDa

ID gène: 93166

UniProt: Q9NQX0

Pathways: Regulation of Muscle Cell Differentiation