CD180 anticorps

N° du produit ABIN614758

Détail du produit anti-CD180 anticorps

Antigène: CD180 (CD180 Molecule (CD180))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD180 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Specificité: This antibody detects CD180.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein-A affinity chromatography

Pureté: > 95 % pure by SDS-PAGE

Immunogène: Human tonsillar B cells

Clone: G28-8

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS with 15 mM sodium azide, approx. pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur CD180

Antigène: CD180 (CD180 Molecule (CD180))

Autre désignation: CD180 / RP105 (CD180 Produits)

Synonymes: anticorps Ly78, anticorps CD180, anticorps LY64, anticorps RP105, anticorps F630107B15, anticorps CD180 molecule, anticorps CD180 antigen, anticorps Cd180, anticorps CD180

Sujet: CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.Synonyms: LY64, Lymphocyte antigen 64, Radioprotective 105 kDa protein

ID gène: 4064

NCBI Accession: NP_005573

UniProt: Q99467

Pathways: Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades