SMPD3 anticorps (AA 416-655)

N° du produit ABIN6148146

Cet anticorps Lapin Polyclonal détecte spécifiquement SMPD3 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour SMPD3 anticorps (AA 416-655) (ABIN6148146)

Antigène: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMPD3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SMPD3 anticorps

Épitope: AA 416-655

Séquence: MDVAYHCYPN KCNDDALASK GALFLKVQVG STPQDQRIVG YIACTHLHAP QEDSAIRCGQ LDLLQDWLAD FRKSTSSSSA ANPEELVAFD VVCGDFNFDN CSSDDKLEQQ HSLFTHYRDP CRLGPGEEKP WAIGTLLDTN GLYDEDVCTP DNLQKVLESE EGRREYLAFP TSKSSGQKGR KELLKGNGRR IDYMLHAEEG LCPDWKAEVE EFSFITQLSG LTDHLPVAMR LMVSSGEEEA

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 416-655 of human SMPD3 (NP_061137.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:1000 - 1:3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SMPD3

Antigène: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Autre désignation: SMPD3

Sujet: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. Binds to anionic phospholipids (APLs such as phosphatidylserine (PS and phosphatidic acid (PA that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity.,SMPD3,NSMASE2,Cell Biology & Developmental Biology,Apoptosis,Neuroscience,Cell Type Marker,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Oligodendrocyte marker,Neuron marker,SMPD3

Poids moléculaire: 70 kDa/71 kDa

ID gène: 55512

UniProt: Q9NY59

Pathways: Hormone Transport