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WWTR1 anticorps (AA 1-230)

WWTR1 Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6150278
  • Antigène Voir toutes WWTR1 Anticorps
    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
    Épitope
    • 11
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    AA 1-230
    Reactivité
    • 37
    • 16
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 33
    • 4
    Lapin
    Clonalité
    • 33
    • 4
    Polyclonal
    Conjugué
    • 22
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp WWTR1 est non-conjugé
    Application
    • 30
    • 16
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Séquence
    MNPASAPPPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA GAAGSPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT TWQDPRKAMN QPLNHMNLHP AVSSTPVPQR SMAVSQPNLV MNHQHQQQMA PSTLSQQNHP TQNPPAGLMS MPNALTTQQQ
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human TAZ (NP_056287.1).
    Isotype
    IgG
  • Indications d'application
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    Commentaires

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
    Autre désignation
    WWTR1 (WWTR1 Produits)
    Synonymes
    anticorps WWTR1, anticorps TAZ, anticorps 2310058J06Rik, anticorps 2610021I22Rik, anticorps C78399, anticorps Taz, anticorps WW domain containing transcription regulator 1 L homeolog, anticorps WW domain containing transcription regulator 1, anticorps wwtr1.L, anticorps wwtr1, anticorps WWTR1, anticorps Wwtr1
    Sujet
    Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.,WW domain-containing transcription regulator protein 1,Transcriptional coactivator with PDZ-binding motif,TAZ,WWTR1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Hippo Signaling Pathway,Stem Cells,Mesenchymal Stem Cells,WWTR1
    Poids moléculaire
    44 kDa
    ID gène
    25937
    UniProt
    Q9GZV5
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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