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Zona Pellucida Glycoprotein 3 anticorps (AA 250-350)

ZP3 Reactivité: Humain WB, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6150536
  • Antigène Voir toutes Zona Pellucida Glycoprotein 3 (ZP3) Anticorps
    Zona Pellucida Glycoprotein 3 (ZP3)
    Épitope
    • 9
    • 8
    • 6
    • 2
    • 1
    AA 250-350
    Reactivité
    • 22
    • 3
    • 3
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 20
    • 2
    Lapin
    Clonalité
    • 22
    Polyclonal
    Conjugué
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Zona Pellucida Glycoprotein 3 est non-conjugé
    Application
    • 20
    • 14
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Séquence
    AFKVPRPGPD TLQFTVDVFH FANDSRNMIY ITCHLKVTLA EQDPDELNKA CSFSKPSNSW FPVEGSADIC QCCNKGDCGT PSHSRRQPHV MSQWSRSASR N
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Immunogène
    A synthetic peptide corresponding to a sequence within amino acids 250-350 of human ZP3 (NP_001103824.1).
    Isotype
    IgG
    Top Product
    Discover our top product ZP3 Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    Zona Pellucida Glycoprotein 3 (ZP3)
    Autre désignation
    ZP3 (ZP3 Produits)
    Synonymes
    anticorps ZP3A, anticorps ZP3B, anticorps ZPC, anticorps Zp-3, anticorps zp3.2, anticorps Zp-3B, anticorps zona pellucida glycoprotein 3, anticorps zona pellucida sperm-binding protein 3, anticorps ZP3, anticorps zp3, anticorps Zp3
    Sujet
    The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.,ZP3,ZP3A,ZP3B,ZPC,Zp-3,ZP3
    Poids moléculaire
    41 kDa/47 kDa
    ID gène
    7784
    UniProt
    P21754
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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