ZRANB3 anticorps (AA 818-1077)

N° du produit ABIN6150540

Cet anticorps anti-ZRANB3 est un anticorps Lapin Polyclonal détectant ZRANB3 dans WB. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour ZRANB3 anticorps (AA 818-1077) (ABIN6150540)

Antigène: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZRANB3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ZRANB3 anticorps

Épitope: AA 818-1077

Séquence: ITKQQTKQNC TKRYITKEDV AVASMDKVKN VGGHVRLITK ESRPRDPFTK KLLEDGACVP FLNPYTVQAD LTVKPSTSKG YLQAVDNEGN PLCLRCQQPT CQTKQACKAN SWDSRFCSLK CQEEFWIRSN NSYLRAKVFE TEHGVCQLCN VNAQELFLRL RDAPKSQRKN LLYATWTSKL PLEQLNEMIR NPGEGHFWQV DHIKPVYGGG GQCSLDNLQT LCTVCHKERT ARQAKERSQV RRQSLASKHG SDITRFLVKK

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 818-1077 of human ZRANB3 (NP_001273497.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:1000 - 1:3000

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-ZRANB3 (ABIN6150540)

Margalef, Kotsantis, Borel, Bellelli, Panier, Boulton: "Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe." dans: Cell, Vol. 172, Issue 3, pp. 439-453.e14, (2019) (PubMed).

Détails sur ZRANB3

Antigène: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Autre désignation: ZRANB3

Sujet: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.,ZRANB3,4933425L19Rik,AH2,Epigenetics & Nuclear Signaling,ZRANB3

Poids moléculaire: 42 kDa/49 kDa/67 kDa/123 kDa

ID gène: 84083

UniProt: Q5FWF4