ZRANB3 anticorps (AA 818-1077)

N° du produit ABIN6150540

Détail du produit anti-ZRANB3 anticorps

Antigène: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Épitope: AA 818-1077

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZRANB3 est non-conjugé

Application: Western Blotting (WB)

Séquence: ITKQQTKQNC TKRYITKEDV AVASMDKVKN VGGHVRLITK ESRPRDPFTK KLLEDGACVP FLNPYTVQAD LTVKPSTSKG YLQAVDNEGN PLCLRCQQPT CQTKQACKAN SWDSRFCSLK CQEEFWIRSN NSYLRAKVFE TEHGVCQLCN VNAQELFLRL RDAPKSQRKN LLYATWTSKL PLEQLNEMIR NPGEGHFWQV DHIKPVYGGG GQCSLDNLQT LCTVCHKERT ARQAKERSQV RRQSLASKHG SDITRFLVKK

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 818-1077 of human ZRANB3 (NP_001273497.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:1000 - 1:3000

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-ZRANB3 (ABIN6150540)

Margalef, Kotsantis, Borel, Bellelli, Panier, Boulton: "Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe." dans: Cell, Vol. 172, Issue 3, pp. 439-453.e14, (2019) (PubMed).

Détails sur ZRANB3

Antigène: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Autre désignation: ZRANB3 (ZRANB3 Produits)

Synonymes: anticorps 4933425L19Rik, anticorps AH2, anticorps AI316834, anticorps C730006D09, anticorps zinc finger RANBP2-type containing 3, anticorps zinc finger, RAN-binding domain containing 3, anticorps ZRANB3, anticorps Zranb3

Sujet: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.,ZRANB3,4933425L19Rik,AH2,Epigenetics & Nuclear Signaling,ZRANB3

Poids moléculaire: 42 kDa/49 kDa/67 kDa/123 kDa

ID gène: 84083

UniProt: Q5FWF4