PDIA4 anticorps (AA 623-638)

N° du produit ABIN615311

L’anticorps anti-PDIA4 Polyclonal Lapin est utilisé pour la détection de PDIA4 dans des échantillons de Souris. Il a été validé pour WB et IHC (p).

Aperçu rapide pour PDIA4 anticorps (AA 623-638) (ABIN615311)

Antigène: PDIA4 (Protein Disulfide Isomerase Family A, Member 4 (PDIA4))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDIA4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PDIA4 anticorps

Épitope: AA 623-638

Specificité: This antibody reacts to Protein Disulfide Isomerase Family A, Member 4 (PDIA4).

Réactivité croisée (Details): Species reactivity (expected):Bovine, Canine, Guinea pig, Hamster, Human, Monkey, Rabbit, Rat.
Species reactivity (tested):Mouse.

Purification: Protein A Chromatography

Immunogène: PDIA4 antibody was raised against a synthetic peptide based on the sequence of mouse ERp72 (residues 623-638) with a cysteine residue added and coupled to KLH.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.09 % azide and 50 % glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur PDIA4

Antigène: PDIA4 (Protein Disulfide Isomerase Family A, Member 4 (PDIA4))

Autre désignation: PDIA4

Sujet: Endoplasmic reticulum protein (ERp) 72 is a member of the protein disulfide isomerase (PDI) family1 that is localized to the endoplasmic reticulum. It contains three repeats of the thioredoxin-like regions that is postulated to represent three independently acting catalytic domains (CGHC) of PDI activity. ERp72 contains the sequence at its carboxyl terminus which serves as its ER retention signal. Together with other ER resident proteins such as BiP, GRP94, and PDI, they serve as the molecular chaperones for proper folding of newly translocated and glycolsylated proteins such as thyroglobulin (Tg) and human chorionic gonadotropin (hCG)-b. ERp72 expression is regulated by the level of misfolding proteins in the ER, as the amount of ERp72 increased in response to epithelial ischemia, a condition that perturbs the maturation of secretory proteins.Synonyms: ER marker, ER protein 70, ER protein 72, ERP70, ERP72, ERp-70, ERp-72, Endoplasmic reticulum resident protein 70, Endoplasmic reticulum resident protein 72, Protein Disulfide Isomerase, Protein disulfide-isomerase A4

ID gène: 9601

NCBI Accession: NP_004902

UniProt: P13667

Pathways: Thyroid Hormone Synthesis, Cell RedoxHomeostasis