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FAT Atypical Cadherin 2 (FAT2) anticorps (CF®488A)

FAT2 Reactivité: Humain IF, FACS, IHC Hôte: Souris Monoclonal 8C5 CF®488A
N° du produit ABIN6155413
  • Antigène Voir toutes FAT Atypical Cadherin 2 (FAT2) Anticorps
    FAT Atypical Cadherin 2 (FAT2)
    Reactivité
    • 14
    • 1
    • 1
    Humain
    Hôte
    • 9
    • 5
    Souris
    Clonalité
    • 9
    • 5
    Monoclonal
    Conjugué
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    CF®488A
    Application
    • 10
    • 9
    • 9
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)
    Fonction
    Mouse Monoclonal anti-Protocadherin-FAT2 (8C5), CF488A Conjugate
    Attributs du produit
    This antibody recognizes a protein of 480 kDa, which is identified as FAT2. The cadherins represent a family of Ca2 -dependent adhesion molecules that function to mediate cell-to-cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including ?-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT2 (FAT tumor suppressor homolog 2) is a single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins. FAT2 contains one Laminin G-like domain, two EGF-like domains and 32 cadherin domains and is believed to function as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Immunogène
    Purified recombinant human FAT2 fusion protein
    Clone
    8C5
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product FAT2 Anticorps primaire
  • Indications d'application
    Immunohistology (formalin) 0.5-1 μg/mL
    • Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Immunofluorescence 1-2 μg/mL
    • Optimal dilution for a specific application should be determined by user
    Commentaires

    Esophagus, Cervix, Uterus, Tonsil or Cerebellum.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    100 μg/mL
    Buffer
    PBS/0.1 % BSA/0.05 % azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Protect from light
  • Antigène
    FAT Atypical Cadherin 2 (FAT2)
    Autre désignation
    Protocadherin-FAT2 (FAT2 Produits)
    Synonymes
    anticorps EMI2, anticorps Fath2, anticorps Gm523, anticorps mKIAA0811, anticorps CDHF8, anticorps CDHR9, anticorps HFAT2, anticorps MEGF1, anticorps FAT atypical cadherin 2, anticorps Fat2, anticorps FAT2
    Poids moléculaire
    480 kDa
    ID gène
    2196, 591255
    UniProt
    Q9NYQ8
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