BST2 anticorps (Internal Region)
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- Antigène Voir toutes BST2 Anticorps
- BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))
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Épitope
- Internal Region
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Reactivité
- Humain
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BST2 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Séquence
- C-ELTEAQKGFQ D
- Specificité
- Recognizes CD317 / BST2
- Réactivité croisée (Details)
- Species reactivity (tested):Human.
- Purification
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
- Immunogène
- Peptide with sequence, from the internal region of the protein sequence according to NP_004326.1. Genename: BST2
- Top Product
- Discover our top product BST2 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))
- Autre désignation
- CD317 / BST2 (BST2 Produits)
- Synonymes
- anticorps BST2, anticorps CD317, anticorps TETHERIN, anticorps 2310015I10Rik, anticorps Bst-2, anticorps C87040, anticorps DAMP-1, anticorps GREG, anticorps Damp1, anticorps bone marrow stromal cell antigen 2, anticorps bone marrow stromal antigen 2, anticorps BST2, anticorps LOC618737, anticorps Bst2
- Sujet
- Bone marrow stromal Antigen-2 (BST-2) is a 30- to 36- kDa type II transmembrane protein, consisting of 180 amino acids. It has been shown to form a complex with Rho-GTPase activating protein, RICH2 (1). This complex is essential for the organization of subapical actin cytoskeleton. BST-2 protein is expressed on certain bonemarrow stromal cell lines and on various normal tissues. The expression pattern of BST2 is relatively different form another bone marrow stromal antigen 1 (BST1). The BST-2 gene is located on chromosome 19p13.2. BST-2 surface expression on fibroblast cell lines facilitated the stromal cell-dependent growth of a murine bone marrow-derived pre-B-cell line, DW34. Some studies suggest that BST-2 may be involved in pre-B-cell growth development by regulating their surface molecules and cytokines (2). BST2 is also expressed in synovial cell lines from where the BST2 gene was cloned. BST2 is predominantly expressed in liver, lungs, heart, placenta and lower levels in pancreas, kidney, skeletal muscle and brain. Naturally all human cells possess an antiviral activity that inhibits the release of retrovirus particles, and other enveloped virus particles. This antiviral activity is antagonized by the HIV-1 accessory protein, Vpu. The antiviral activity can be constitutively induced and expressed by interferon-alfa and is consist of protein based Synonyms: BST-2, Bone marrow stromal antigen 2, HM1.24 antigen, Tetherin
- ID gène
- 684
- NCBI Accession
- NP_004326
- UniProt
- Q10589
- Pathways
- Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response
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