BST2 anticorps (Internal Region)

N° du produit ABIN615955

Cet anticorps Chèvre Polyclonal détecte spécifiquement BST2 dans WB et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour BST2 anticorps (Internal Region) (ABIN615955)

Antigène: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp BST2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-BST2 anticorps

Épitope: Internal Region

Séquence: C-ELTEAQKGFQ D

Specificité: Recognizes CD317 / BST2

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence, from the internal region of the protein sequence according to NP_004326.1. Genename: BST2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur BST2

Antigène: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Autre désignation: CD317 / BST2

Sujet: Bone marrow stromal Antigen-2 (BST-2) is a 30- to 36- kDa type II transmembrane protein, consisting of 180 amino acids. It has been shown to form a complex with Rho-GTPase activating protein, RICH2 (1). This complex is essential for the organization of subapical actin cytoskeleton. BST-2 protein is expressed on certain bonemarrow stromal cell lines and on various normal tissues. The expression pattern of BST2 is relatively different form another bone marrow stromal antigen 1 (BST1). The BST-2 gene is located on chromosome 19p13.2. BST-2 surface expression on fibroblast cell lines facilitated the stromal cell-dependent growth of a murine bone marrow-derived pre-B-cell line, DW34. Some studies suggest that BST-2 may be involved in pre-B-cell growth development by regulating their surface molecules and cytokines (2). BST2 is also expressed in synovial cell lines from where the BST2 gene was cloned. BST2 is predominantly expressed in liver, lungs, heart, placenta and lower levels in pancreas, kidney, skeletal muscle and brain. Naturally all human cells possess an antiviral activity that inhibits the release of retrovirus particles, and other enveloped virus particles. This antiviral activity is antagonized by the HIV-1 accessory protein, Vpu. The antiviral activity can be constitutively induced and expressed by interferon-alfa and is consist of protein based Synonyms: BST-2, Bone marrow stromal antigen 2, HM1.24 antigen, Tetherin

ID gène: 684

NCBI Accession: NP_004326

UniProt: Q10589

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response