CCBE1 anticorps (AA 35-406)

N° du produit ABIN616002

Détail du produit anti-CCBE1 anticorps

Antigène: CCBE1 (Collagen and Calcium Binding EGF Domains 1 (CCBE1))

Épitope: AA 35-406

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCBE1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects CCBE1.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein-A chromatography

Immunogène: Highly pure (>95%) recombinant human ccbe1 (Tyr35-Pro406) derived from Sf9 insect cells

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: The lyophilized antibody is stable at room temperature for up to 1 month. Following reconstitution antibody can be stored at 2-8 °C for up to two weeks or (in aliquots) at -20 °C for longer.

Détails sur CCBE1

Antigène: CCBE1 (Collagen and Calcium Binding EGF Domains 1 (CCBE1))

Autre désignation: CCBE1 (CCBE1 Produits)

Synonymes: anticorps 4933426F18Rik, anticorps 9430093N24Rik, anticorps mKIAA1983, anticorps RGD1307670, anticorps fof, anticorps collagen and calcium binding EGF domains 1, anticorps CCBE1, anticorps Ccbe1, anticorps ccbe1

Sujet: The lymphatic system comprises a vascular system separate from the cardiovascular system, essential for immune responses, fluid homeostasis and fat absorption. Lymphatic vessels develop in a complex process termed lymphangiogenesis that involves budding, migration and proliferation of lymphatic endothelial progenitor cells. A few genes, such as FLT4, FOXC2 and SOX18, are known to be critically involved in lymph vessel formation in humans. Lymphedema, lymphangiectasias, mental retardation and unusual facial characteristics define the autosomal recessive Hennekam syndrome. Homozygosity mapping identified a critical chromosomal region containing ccbe1, encoding Collagen and Calcium-Binding EGF-domain-1, a secreted protein which is required for embryonic lymphangiogenesis in zebrafish. ccbe1 is not expressed in endothelial cells of lymph vessels, and it may be a component of the extracellular matrix. In zebrafish, ccbe1 expression was observed along the earliest migration routes of endothelial cells that sprout from the posterior cardinal vein and migrate circuitously before developing into lymphatic vessels. ccbe1 might therefore be involved in guidance of these migrating cells.Synonyms: Collagen and calcium-binding EGF domain-containing protein 1, Full of fluid protein homolog, KIAA1983

ID gène: 147372

NCBI Accession: NP_597716

UniProt: Q6UXH8