MVP anticorps (CF®488A)

N° du produit ABIN6165331

L’anticorps Souris Monoclonal anti-MVP a été validé pour FACS et IF. Il convient pour détecter MVP dans des échantillons de Humain.

Aperçu rapide pour MVP anticorps (CF®488A) (ABIN6165331)

Antigène: MVP (Major Vault Protein (MVP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MVP est conjugé à/à la CF®488A

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 1014

Détail du produit anti-MVP anticorps (CF®488A)

Fonction: Mouse Monoclonal anti-Major Vault Protein (MVP) (1014), CF488A Conjugate

Attributs du produit: This antibody recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70 % of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Proteins precipitated from human breast cancer MCF-7 cells

Isotype: IgG1 kappa

Information d'application

Indications d'application: Immunofluorescence 0.5-1 μg/mL

• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

MCF-7/HeLa, breast tumors

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Détails sur MVP

Antigène: MVP (Major Vault Protein (MVP))

Sujet: Lung resistance-related protein (LRP), Major Vault Protein, MVP, VAULT1

Poids moléculaire: 104-110 kDa

ID gène: 9961, 632177

UniProt: Q14764