CD46 anticorps

N° du produit ABIN616770

Détail du produit anti-CD46 anticorps

Antigène: CD46

Reactivité: Humain, Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD46 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificité: This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast, it is negative on erythrocytes.

Réactivité croisée (Details): Species reactivity (tested):Human, bovine

Purification: Protein-A affinity chromatography

Pureté: > 95 % pure by SDS-PAGE

Immunogène: HPB-ALL human T cell line

Clone: MEM-258

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μm filter sterilized

Agent conservateur: Azide free

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CD46

Antigène: CD46

Autre désignation: CD46 / MCP (CD46 Produits)

Synonymes: anticorps AHUS2, anticorps MCP, anticorps MIC10, anticorps TLX, anticorps TRA2.10, anticorps Mcp, anticorps CD46, anticorps CD46 molecule, anticorps CD46 antigen, complement regulatory protein, anticorps CD46 molecule, complement regulatory protein, anticorps membrane cofactor protein-like, anticorps CD46, anticorps Cd46, anticorps LOC100341359, anticorps LOC103789310

Sujet: CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.Synonyms: MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen

ID gène: 4179

NCBI Accession: NP_002380

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization