Transgelin anticorps (CF®405S)

N° du produit ABIN6167703

Cet anticorps Souris Monoclonal détecte spécifiquement Transgelin dans FACS et IF. Il présente une réactivité envers Humain, Souris, Lapin, Boeuf (Vache) et Porc.

Aperçu rapide pour Transgelin anticorps (CF®405S) (ABIN6167703)

Antigène: Transgelin (TAGLN)

Reactivité: Humain, Souris, Lapin, Boeuf (Vache), Porc

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Transgelin est conjugé à/à la CF®405S

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: TAGLN-247

Détail du produit anti-Transgelin anticorps (CF®405S)

Fonction: Mouse Monoclonal anti-Transgelin / SM22-alpha (TAGLN/247), CF405S Conjugate

Attributs du produit: This MAb recognizes a 22 kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant full-length human transgelin (TAGLN) protein.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow Cytometry 0.5-1 μg/million cells/0.1 mLImmunofluorescence 1-2 μg/mL

Commentaires:

U-2 OS, Hs68 or WI 38 cells. Colon carcinoma.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Détails sur Transgelin

Antigène: Transgelin (TAGLN)

Autre désignation: Transgelin / SM22-alpha

Poids moléculaire: 22 kDa

ID gène: 6876, 410977

UniProt: Q01995