CCR5 anticorps (CF®488A)

N° du produit ABIN6168658

Détail du produit anti-CCR5 anticorps (CF®488A)

Antigène: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCR5 est conjugé à/à la CF®488A

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Fonction: Mouse Monoclonal anti-CD195 / CCR-5 (12D1), CF488A Conjugate

Attributs du produit: This antibody reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Human native CCR5 protein

Clone: 12D1-

Isotype: IgG2a kappa

Information d'application

Indications d'application: Immunofluorescence 0.5-1 μg/mL Immunohistology Frozen 0.5-1.0 μg/mL

• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

Human lymph node and tonsil.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Détails sur CCR5

Antigène: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Autre désignation: CD195 / CCR-5 (CCR5 Produits)

Synonymes: anticorps CC-CKR-5, anticorps CCCKR5, anticorps CCR-5, anticorps CD195, anticorps CKR-5, anticorps CKR5, anticorps CMKBR5, anticorps IDDM22, anticorps Ckr5, anticorps Cmkbr5, anticorps CCR1-L, anticorps GPCR, anticorps CCR5, anticorps AM4-7, anticorps C-C motif chemokine receptor 5 (gene/pseudogene), anticorps chemokine (C-C motif) receptor 5, anticorps C-C motif chemokine receptor 5, anticorps CCR5, anticorps Ccr5

Sujet: CC Chemokine Receptor Type 5, CC-CKR-5, CCCKR5, CCR5, Chemokine CC motif receptor 5, Chemokine receptor CCR5, CHEMR13, CKR5, CMKBR5, HIV-1 fusion coreceptor, IDDM22, MIP-1 alpha receptor

Poids moléculaire: 45 kDa

ID gène: 1234, 450802

UniProt: P51681

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size