SOX10 anticorps (AA 115-269) (CF®405S)
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- Antigène Voir toutes SOX10 Anticorps
- SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
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Épitope
- AA 115-269
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp SOX10 est conjugé à/à la CF®405S
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)
- Fonction
- Mouse Monoclonal anti-SOX10 (SOX10/992), CF405S Conjugate
- Attributs du produit
- This antibody recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogène
- Recombinant fragment (aa 115-269) of human SOX10 protein with hexa-histidine tag
- Clone
- SOX10-992
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product SOX10 Anticorps primaire
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- Indications d'application
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Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Western blotting 0.5-1.0 μg/mL
- Optimal dilution for a specific application should be determined by user
- Commentaires
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HepG2 cells. Melanomas, breast carcinomas, gliomas.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Protect from light
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- Antigène
- SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
- Autre désignation
- SOX10 (SOX10 Produits)
- Synonymes
- anticorps DOM, anticorps PCWH, anticorps WS2E, anticorps WS4, anticorps WS4C, anticorps SOX-10, anticorps SOX10, anticorps dom, anticorps ws4, anticorps Dom, anticorps Sox21, anticorps SOX9, anticorps cls/sox10, anticorps zgc:100757, anticorps SRY-box 10, anticorps SRY box 10, anticorps SRY-box 10 L homeolog, anticorps SRY (sex determining region Y)-box 10, anticorps SOX10, anticorps Sox10, anticorps sox10.L, anticorps sox10
- Sujet
- DOM, PCWH, SOX10, SRY (sex determining region Y) box 10, SRY box containing gene 10, SRY related HMG box gene 10, Waardenburg syndrome type 2E (WS2E), WS4, Waardenburg syndrome type 4C (WS4C)
- Poids moléculaire
- 49-58 kDa
- ID gène
- 6663, 376984
- UniProt
- P56693
- Pathways
- Chromatin Binding
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