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SOX10 anticorps (AA 115-269)

SOX10 Reactivité: Humain WB, ELISA, Coat Hôte: Souris Monoclonal SOX10-992 unconjugated
N° du produit ABIN6940624
  • Antigène Voir toutes SOX10 Anticorps
    SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
    Épitope
    • 33
    • 16
    • 10
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 115-269
    Reactivité
    • 86
    • 54
    • 39
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 68
    • 37
    • 2
    Souris
    Clonalité
    • 55
    • 52
    Monoclonal
    Conjugué
    • 49
    • 9
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SOX10 est non-conjugé
    Application
    • 82
    • 37
    • 29
    • 28
    • 28
    • 18
    • 15
    • 14
    • 12
    • 10
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Coating (Coat)
    Specificité
    The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant human SOX10 protein fragment (aa115-269)
    Clone
    SOX10-992
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product SOX10 Anticorps primaire
  • Indications d'application

    Positive Control: HepG2 cells. Melanomas, breast carcinomas, gliomas.

    Known Application: ELISA (For coating, purchase antibody without BSA), Western Blot (0.5-1.0 μg/mL)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
    Autre désignation
    SOX10 (SOX10 Produits)
    Synonymes
    anticorps DOM, anticorps PCWH, anticorps WS2E, anticorps WS4, anticorps WS4C, anticorps SOX-10, anticorps SOX10, anticorps dom, anticorps ws4, anticorps Dom, anticorps Sox21, anticorps SOX9, anticorps cls/sox10, anticorps zgc:100757, anticorps SRY-box 10, anticorps SRY box 10, anticorps SRY-box 10 L homeolog, anticorps SRY (sex determining region Y)-box 10, anticorps SOX10, anticorps Sox10, anticorps sox10.L, anticorps sox10
    Poids moléculaire
    49-58kDa
    ID gène
    6663
    UniProt
    P56693
    Pathways
    Chromatin Binding
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